Almost two-thirds of Ontario seniors who received vitamin B12 shots had no evidence of a B12 deficiency, according to a study published in the medical journal JAMA Internal Medicine.
The study used databases at the Toronto-based Institute for Clinical Evaluative Sciences to review the patient records of 146,850 residents of the province aged 65 or over who were prescribed regular vitamin B12 shot between January 2011 and October 2015.
Of those, 93,615 (64 per cent) either had tests confirm they already had normal B12 levels, or they weren’t tested at all.
“We know that’s a lot of inappropriate care that happens in Canada,” said study co-author Dr. William Silverstein of the University of Toronto. “But we were quite surprised that it was the number was as high as it was.”
Silverstein and his colleagues calculated the inappropriately prescribed shots needlessly cost the province’s health-care system $45.6 million annually.
Tablets just as effective
Over-the-counter B12 tablets are a fraction of the cost of shots, and have been shown in a British-Canadian study to work just as well for most people, although some people with digestive conditions may have difficulty absorbing the vitamin in tablet form.
B12 is found in animal-based sources such as meat, fish, poultry, eggs, and dairy products.
People who don’t get enough of the essential vitamin can experience nausea, fatigue, dizziness or depression among other symptoms. Long-term deficiency can lead to cognitive problems.
Research suggests about 20 per cent of elderly people are B12 deficient. Although a Statistics Canada population survey published in 2013 found, on average, seniors had only slightly lower levels of B12 than younger adults.
Vegans and “patients with diseases like Crohn’s and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency,” added Silverstein.
The Toronto specialist said that the price tag for a monthly shot is $44.33 — $33.70 paid to the doctor per visit, $6.74 for administering the shot and $3.89 for the vial of B12.
Orally administered supplements from a big box store cost as little as $30 for a full year’s supply of tablets.
Silverstein said he decided to investigate the over-prescribing of B12 shots, because “as an internal medicine resident, I have seen many patients come into the emergency department, and they were getting B12 injections without having a really good reason for it.”
His study could not determine why family physicians were prescribing it inappropriately — including whether it was initiated by the doctor or at the request of the patient. Silverstein also said he didn’t know if over-prescription was a problem in other provinces.
B12’s star power
B12 shots have gained popularity after being used by celebrities, such as Rihanna and Katy Perry, because they’re promoted as a means to boost energy levels. Injections or vitamin drips are also offered by naturopathic doctors and spas promising instant results.
But Dr. Samir Sinha, who was not involved in the research, said B12 shots can’t provide “a big boost.”
“Getting B12 shouldn’t instantly make you feel great or more powerful,” he said. “People who really believe that … that’s the power of placebo.”
Otherwise he said it’s ineffective to take B12 supplements to prevent deficiency — and there are even potential risks of over-doing it.
Only a handful of people
Sinha pointed to a recent study published in the online journal of JAMA which found an association between high intakes of vitamins B6 and B12 and hip fractures in older women.
Sinha said he only prescribes shots to patients for whom tablets can’t be absorbed properly during digestion. “I’d say maybe only a handful of people at most in the last 10 years have I ever actually thought would benefit from B12 injections.”
As to why some physicians would be needlessly prescribing B12 shots, he said, “It may be just habit. But clearly I think what the study showed was that this is a practice that’s probably happening more often in Ontario than it should be happening.”
Dr. William Silverstein, a recent graduate of medical school, remembered that little time was spent on the appropriate treatment of B12 deficiency, “I recall there was one slide in my class that said you treat B12 deficiency with a pill or an injection. And that was it.”